vGrapefruit Juice (GFJ) can increase the risk of Adverse effects of drugs such as Simvastatin, Lovastatin, Atorvastatin, Domperidone, Dronedarone, Lurasidone, Amiodarone, Quinine,, Quinidine, Erythromycin, Crizotinib, Dasatinib, Lapatinib, Nilotinib, Pazopanib, Sunitinib, Vandetanib, Venurafenib, Rilpivirine, Pimozide, Ziprasidone, Cyclosporine, Tacrolimus, Sirolimus, Everolimus, Ketamine (oral), Fentanyl (oral), Alfentanil (oral), Oxycodone, Apixaban, Rivaroxaban, Ticagrelor, Felodipine, Nifedipine, Dextromethorphan, etc.
vThe oral availability of Felodipine and Dextromethorphan found to be increased by coadministration of Seville orange juice. Theoretically Seville orange juice could interact with the same range of drugs as grapefruit through the inhibition of intestinal CYP3A4.
vPomelo juice was found to have substantial furanocoumarin content and to cause inhibition of CYP3A4 enzyme. The blood concentrations of drugs like Felodipine, Cyclosporine and Tacrolimus has been demonstrated to be elevated by the consumption of Pomelo juice.
vLime juice was found to contain high bergamottin (Furanocoumarin) content and consumption of as little as 62 mL of lime juice may produce a relevant drug interaction in Grapefruit juice (GFJ) sensitive individuals.
vThe adverse effects of drugs such as Carbamazepine, Amitriptyline, Codeine, Desipramine, Flecainide, Fluoxetine, Ondansetron, Tramadol, Captopril, Enalapril, Lisinopril, Ramipril and Rosuvastatin could be increased by the consumption of Pomegranate juice.
vApple juice can interact with drugs like Fexofenadine, Cyclosporine and Aliskiren and reduce their efficacy through the inhibition of Organic Anion Transporting Polypeptide 2B1 (OATP2B1) mediated absorption.
vOATP mediated absorption of drugs such as Atenolol, Celiprolol, Ciprofloxacin, Levofloxacin, Clofazimine, Fexofenadine, Itraconazole, Montelukast, Aliskiren, etc. decreased by the consumption of Orange Juice.
vPatients must ask their doctor or pharmacist if their medicines have the potential to interact with fruit juices.
vBy educating the patients about potential fruit juice interactions, the Pharmacists and other health professionals could minimize the adverse drug interactions of Fruit juices.
