Drug Interactions of Thiazide Diuretics:
© Thiazide diuretics are useful to treat hypertension and edema.
© Thiazide diuretics include Hydrochlorothiazide, Chlorthalidone, Indapamide and Metolazone.
© Thiazide diuretics block Na+-Cl− symporter of distal convoluted tubules and inhibit the reabsorption of sodium (Na+) and chloride (Cl−).
© Thiazide Diuretics can interact majorly with drugs such as Digoxin, Digitoxin, Flecainide, Dofetilide, Bepridil, Lithium, and Arsenic Trioxide.
© Moderate interaction of Thiazide Diuretics includes ACE Inhibitors, NSAIDs, Antidiabetics, Licorice, Ginkgo, Gossypol and Calcium.
© Frequent monitoring of potassium and magnesium is recommended when Thiazide Diuretics and Digitalis glycosides (Digoxin, Digitoxin) are used together.
© Concomitant use of Thiazide diuretics and Flecainide, Dofetilide, Bepridil or Arsenic Trioxide warrants the monitoring of rhythm.
© Lithium toxicity (Weakness, Tremor, Excessive thirst, Confusion) can occur due to decreased lithium clearance induced by Thiazide diuretics.
© Monitor for hypotension, fluid status, and body weight regularly for up to two weeks after the initiation of ACE Inhibitors (Captopril, Lisinopril, Perindopril, etc.) in patients taking Thiazide diuretics.
© The patients taking both Thiazide diuretics and NSAIDs (Ibuprofen, Diclofenac, Naproxen, etc.) should be monitored for diuretic efficacy and for signs of renal failure.
© Concomitant use of a diuretic and an Antidiabetic agent warrants the monitoring of glucose levels more frequently.
© Avoid using Licorice in patients taking Thiazide Diuretics due to increased risk of Hypokalemia.
© Concomitant use of Ginkgo and thiazide diuretics may increase the blood pressure and requires cautious monitoring.
© Gossypol use should be discontinued during diuretic treatment due to elevated risk of Hypokalemia.
© Avoid excessive ingestion of Calcium while receiving thiazide diuretics.
© The patients with hypertension should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.
