More presentations from Naina Mohamed Pakkir Maideen
> Hypothyroidism is a condition in which the Thyroid gland is underactive and produces insufficient Thyroid hormone.
Ø Symptoms of
Hypothyroidism include…
· Fatigue
· Weakness
· Weight gain
· Dry, rough pale skin
· Dry hair
· Hair loss
· Cold intolerance
· Muscle cramps
and frequent muscle aches
· Constipation
· Depression
· Irritability
· Memory loss
· Abnormal
menstrual cycles
· Decreased libido
Ø Levothyroxine
may interact significantly with drugs such as…
· Estrogens
· Calcium supplements
· Iron supplements
· Proton Pump
Inhibitors
· Simvastatin
· Tricyclic or
Tetracyclic Antidepressants
· Ketamine
· Bile acid
sequestrants (Cholestyramine, Colestipol, Colesevelam)
· Ciprofloxacin
· Oral
Anticoagulants
· Antacids,
Orlistat Or Sucralfate
· CYP3A4 Inducers
(Phenobarbital, Carbamazepine,
Phenytoin, Rifampin)
Ø Drug
interactions can result in significant morbidity and mortality and thus
minimizing the risk for drug interactions should be a goal in drug therapy.
Ø The patients
with Hypothyroidism should bring a list of all of the drugs they are taking
including prescription drugs, over-the-counter drugs, and any supplements,
herbal or otherwise, during their visit to the doctor or pharmacist.
Ø The risk of
adverse effects could be reduced by healthcare professionals through the
screening, education, and follow up on suspected drug interactions.
Ø If possible, the
patients are recommended to fill all their prescriptions at one pharmacy.
