More Presentations from Naina Mohamed, PhD
© Fibrinolytics are the medications which breakdown the fibrin inside the clot
(Thrombus) but not the thrombus itself.
© Thrombolytics are the agents, which can break down the whole thrombus (Clot)
itself. Heparin acts as an indirect thrombolytic agent.
© Anticoagulants are the drugs affecting blood coagulation factors and used to
prevent harmful blood clots, which can cause serious conditions like Deep Vein
Thrombosis (DVT), Pulmonary Embolism (PE), or a Stroke.
© Anticoagulants work before the thrombus formation and they cannot
dissolve the clot (Thrombus) once it is formed.
© Hence, Fibrinolytics (Thrombolytics) are administered following a Heart
attack, Stroke and Pulmonary embolism to dissolve the thrombus blocking
the blood vessels.
© Fibrinolytics include…
Ø Recombinant Tissue Plasminogen Activators (rtPA)
o
Alteplase
o
Reteplase
o
Tenecteplase
Ø Streptokinase
Ø Urokinase
© Mechanism of action of Fibrinolytics:
© Interaction between one or more coadministered medications leading
to change in their effectiveness or toxicity, is termed as “Adverse drug
interaction”.
© It is Contraindicated to use Fibrinolytics and Defibrotide
concomitantly.
© Drugs increasing the risk of
Fibrinolytics associated Bleeding include…
o
Anticoagulants (Warfarin,
Heparin, Enoxaparin, Dabigatran, etc)
o
Antiplatelet agents
(Aspirin, Clopidogrel, etc)
o Pentosan
Polysulfate Sodium
©
Herbs
increasing the risk of Fibrinolytics associated Bleeding include…
o
Fenugreek
o
Garlic
o
Ginkgo
o
Evening Primrose Oil
o
Clove Oil
o
Anise
o
Turmeric (Curcumin)
o
Licorice
o
Asafetida
o
Capsicum (Capsaicin)
o
Celery
o
Kava
o
Cat's claw
o
Medowsweet
o
Feverfew
o
Tan-shen
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients on Anticoagulants about their herbal and other
alternative medicine product use.
