Drug Interactions of Dipyridamole (Adenosine Reuptake Inhibitor):
© Dipyridamole is an Adenosine reuptake inhibitor.
© Dipyridamole is used to prevent blood clots after heart valve
replacement in combination with Anticoagulants
© The risk of hypotension is higher in patients taking Riociguat and Dipyridamole
(nonspecific PDE inhibitor).
© Drugs increasing Dipyridamole associated bleeding include…
Ø ADP receptor blockers (Clopidogrel,
Prasugrel, Ticagrelor, Ticlopidine, etc.)
Ø Glycoprotein IIB/IIIA
inhibitors (Abciximab, Tirofiban, etc.)
Ø Fibrinolytics (Reteplase,
Tenecteplase, Streptokinase, etc.)
Ø Treprostinil
Ø Sulfinpyrazone
Ø Ginkgo
© Concomitant use of Adenosine and Dipyridamole may
result in Adenosine toxicity (Hypotension, Dyspnea, Vomiting, etc). Patients
taking Dipyridamole should be administered with lower doses of adenosine.
© Regadenoson is an adenosine receptor agonist and its use in patients taking
dipyridamole increases the risk of toxicity (Hypotension, bradycardia, heart
block, arrhythmia, and other cardiovascular effects).
© Coadministration of Distigmine with Dipyridamole may result
in decreased distigmine efficacy.
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The patients on antiplatelet therapy should bring a list of all of
the drugs they are taking including prescription drugs, over-the-counter drugs,
and any supplements, herbal or otherwise, during their visit to the doctor or
pharmacist.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© If possible, the patients are recommended to fill all their
prescriptions at one pharmacy.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients about their herbal and other alternative
medicine product use.
