Drug Interactions of Cilostazol:
More presentations from Naina Mohamed, PhD
© Cilostazol is a selective inhibitor of phosphodiesterase 3 (PDE3)
and it is an antiplatelet drug and a vasodilator.
© Cilostazol is approved for the treatment of intermittent
claudication in patients with peripheral vascular disease.
© Mechanism of action of Cilostazol:
© Drugs increasing Cilostazol exposure include…
Ø Omeprazole
Ø Fluoxetine
Ø Fluvoxamine
Ø Aspirin
Ø Ticlopidine
Ø Ticagrelor
Ø Nefazodone
Ø Azole antifungals (Ketoconazole,
Fluconazole, Itraconazole)
Ø Idelalisib
Ø Amiodarone
Ø Cobicistat
Ø Piperaquine
Ø Ginkgo
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The patients on antiplatelet therapy should bring a list of all of
the drugs they are taking including prescription drugs, over-the-counter drugs,
and any supplements, herbal or otherwise, during their visit to the doctor or
pharmacist.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© If possible, the patients are recommended to fill all their
prescriptions at one pharmacy.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients about their herbal and other alternative
medicine product use.
