http://journals.sagepub.com/doi/abs/10.1177/2042018818767220
https://www.researchgate.net/publication/324261559_Drug_interactions_of_meglitinide_antidiabetics_involving_CYP_enzymes_and_OATP1B1_transporter
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116761/
https://www.researchgate.net/publication/324261559_Drug_interactions_of_meglitinide_antidiabetics_involving_CYP_enzymes_and_OATP1B1_transporter
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116761/
§ Meglitinides including Repaglinide and Nateglinide are short acting
insulin secretogogues.
§ They are very much useful to treat the patients with Type 2
Diabetes Mellitus having irregular meal timings.
§ Interaction between one or more coadministered medications leading
to reduced therapeutic efficacy or enhanced toxicity is termed as “Adverse
drug interaction”.
§
Mechanism
of action of Meglitinide Antidiabetics:
§ Most of the drug interactions of Metformin result in enhanced risk
of “Hypoglycemia”.
§ Concurrent use of the following drugs along with Repaglinide,
elevate its plasma concentrations and the risk of Hypoglycemia…
ª
Gemfibrozil
ª
Clopidogrel
ª
Cyclosporine
ª
Trimethoprim
ª
Atorvastatin
ª
Nifedipine
§ Drugs interacting with Nateglinide include…
ª
Azole
Antifungals
ª
Rifampicin
§ The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
§ The diabetic patients should always consult their physician and
pharmacist before taking any new medication.
§ The diabetic patients should bring a list of all of the drugs they
are taking (or simply bring the drugs themselves), including prescription
drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during
their visit to the doctor or pharmacist.
§ They are encouraged to ask their doctor or pharmacist to look over
their list for any potentially dangerous combinations.
§ It is recommended that people fill all their prescriptions at one
pharmacy, if possible.
