· Thiazide
diuretics include
Ø Chlorothiazide
Ø Hydrochlorothiazide
· Thiazide-like
diuretics include
Ø Indapamide
Ø Chlorthalidone
· Thiazide
diuretics are primarily prescribed in the management of hypertension and edema
associated with chronic heart failure, renal dysfunction, and hepatic
cirrhosis. Besides, these drugs are also used to treat high blood pressure induced
by corticosteroids and estrogen.
· Drug
interaction resulting from Thiazide-induced hypokalemia
Ø Digoxin
· Drug
interaction resulting from Thiazide-induced hyponatremia
Ø Flecaininde
· Drug
interaction resulting from Thiazide-induced hypovolemia
Ø Dofetilide
· Pharmacological
interaction of Thiazide diuretics
Ø Lithium
Ø ACE
inhibitors
Ø NSAIDs
Ø Antidiabetics
Ø Vitamin D
Ø Herbs
(Licorice and Ginkgo)
· The
prescribers and the pharmacists are required to be aware of the drug
interactions of thiazide diuretics.
