Drug Interactions of Antiplatelets (Part 5):

Drug Interactions of Cilostazol:
 

 
More presentations  from Naina Mohamed, PhD

 

©   Cilostazol is a selective inhibitor of phosphodiesterase 3 (PDE₃) and it is an antiplatelet drug and a vasodilator.

©   Cilostazol is approved for the treatment of intermittent claudication in patients with peripheral vascular disease.

©   Mechanism of action of Cilostazol:

 

 

©   Drugs increasing Cilostazol exposure include…

Ø Omeprazole

Ø Fluoxetine

Ø Fluvoxamine

Ø Aspirin

Ø Ticlopidine

Ø Ticagrelor

Ø Nefazodone

Ø Azole antifungals (Ketoconazole, Fluconazole, Itraconazole)

Ø Idelalisib

Ø Amiodarone

Ø Cobicistat

Ø Piperaquine

Ø Ginkgo

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients on antiplatelet therapy should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients about their herbal and other alternative medicine product use.

 

Drug Interactions of Antiplatelets (Part 4):

Drug Interactions of Glycoprotein IIB/IIIA inhibitors:

More Presentations from Naina Mohamed, PhD

©   Glycoprotein IIB/IIIA inhibitors include Abciximab, Eptifibatide and Tirofiban.

©   They are intended to be administered by intravenous route only.

©    They are frequently used during percutaneous coronary intervention (PCI). They may also be used to treat acute coronary syndromes (ACS).

©   Mechanism of action of Glycoprotein IIB/IIIA inhibitors:

 

©   Drugs increasing Glycoprotein IIB/IIIA inhibitors associated bleeding include…

Ø Other Antiplatelets (Aspirin, Ticlopidine, Dipyridamole, etc.)

Ø Ginkgo

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients on antiplatelet therapy should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients about their herbal and other alternative medicine product use.

Drug Interactions of Antiplatelets (Part 3):

Drug Interactions of Dipyridamole (Adenosine Reuptake Inhibitor):

More presentations from Naina Mohamed, PhD

©   Dipyridamole is an Adenosine reuptake inhibitor.

©   Dipyridamole is used to prevent blood clots after heart valve replacement in combination with Anticoagulants

 

©   The risk of hypotension is higher in patients taking Riociguat and Dipyridamole (nonspecific PDE inhibitor).

©   Drugs increasing Dipyridamole associated bleeding include…

Ø ADP receptor blockers (Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine, etc.)

Ø Glycoprotein IIB/IIIA inhibitors (Abciximab, Tirofiban, etc.)

Ø Fibrinolytics (Reteplase, Tenecteplase, Streptokinase, etc.)

Ø Treprostinil

Ø Sulfinpyrazone

Ø Ginkgo

©   Concomitant use of Adenosine and Dipyridamole may result in Adenosine toxicity (Hypotension, Dyspnea, Vomiting, etc). Patients taking Dipyridamole should be administered with lower doses of adenosine.

©   Regadenoson is an adenosine receptor agonist and its use in patients taking dipyridamole increases the risk of toxicity (Hypotension, bradycardia, heart block, arrhythmia, and other cardiovascular effects).

©   Coadministration of Distigmine with Dipyridamole may result in decreased distigmine efficacy.

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients on antiplatelet therapy should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients about their herbal and other alternative medicine product use.