Drug Interactions of OTC Analgesics (Part 1):

Drug Interactions of Acetaminophen (Paracetamol):

More presentations from Naina Mohamed Pakkir Maideen

ª  Acetaminophen is a most commonly used analgesic drug and can be found in over 200 OTC products.

ª  Concomitant use of Acetaminophen and warfarin may increase the risk of bleeding. Acetaminophen is still the analgesic and antipyretic of choice in warfarin patients, due to lack of a safer alternative.

ª  The risk of hepatotoxicity is elevated by the coadministration of Acetaminophen and CYP enzyme inducers (Carbamazepine, Oxcarbazepine, Phenytoin, Fosphenytoin, Deferasirox, Piperaquine, Barbiturates, Isoniazid, Rifampin, and Rifabutin).

ª  Smokers may need more dose of Acetaminophen due to increased metabolism and the toxicity of Acetaminophen is also increased.

ª  Chronic Alcoholics increase their chances to develop hepatotoxicity by using Acetaminophen.

ª  Presence of food in the GIT may delay the absorption of Acetaminophen and for rapid relief of pain it can be taken on an empty stomach.

ª  Normal therapeutic doses of Acetaminophen for a short period are considered to be safe in Pregnancy and Breast feeding.

ª  Patients should thoroughly read the labels of all over-the-counter and prescription medicines.

ª  Patients should talk to their doctor or pharmacist before taking any new prescription or over the counter medication.

ª  Physicians should be aware of potential drug interactions with OTC medicines when prescribing new medications.

ª  Pharmacists can be instrumental in assisting patients with using OTC medications safely and effectively.

ª  Pharmacists should warn consumers of the risks of misusing OTC pain relievers.