ª Pseudoephedrine is an oral OTC decongestant available commonly.
ª Oxymetazoline and Xylometazoline are topical OTC decongestants and are available as nasal drops or nasal sprays.
ª Concomitant use of Pseudoephedrine and
MAO Inhibitors such as Selegiline, Rasagiline, Clorgyline, Pargyline, Toloxatone, Iproniazid, Moclobemide, Nialamide, Procarbazine, Phenelzine , Isocarboxazid, Tranylcypromine, Furazolidone is contraindicated, due to elevated risk of hypertensive crisis characterized by hypertension, hyperpyrexia and headache.
MAO Inhibitors such as Selegiline, Rasagiline, Clorgyline, Pargyline, Toloxatone, Iproniazid, Moclobemide, Nialamide, Procarbazine, Phenelzine , Isocarboxazid, Tranylcypromine, Furazolidone is contraindicated, due to elevated risk of hypertensive crisis characterized by hypertension, hyperpyrexia and headache.
ª It is contraindicated to use Pseudoephedrine and Linezolid concomitantly, due to increased blood pressure.
ª Co-administration of Pseudoephedrine and Dihydroergotamine is contraindicated, due to extreme elevation of blood pressure.
ª The blood pressure control of Guanethidine and Methyldopa is lost due to concomitant use of Pseudoephedrine.
ª Bitter orange contains synephrine which can interact with Pseudoephedrine and increase the risk of hypertensive crisis.
ª Topical decongestants (Oxymetazoline or Xylometazoline) increase the risk of hypertensive crisis by interacting with MAO Inhibitors.
ª Pseudoephedrine should be avoided during pregnancy, if possible.
ª People with heart disease, high blood pressure, diabetes, hyperthyroidism and enlarged prostate should consult a doctor or pharmacist before they take decongestants because side effects can be dangerous.
ª Physicians should be aware of potential drug interactions with OTC medicines when prescribing new medications.
ª Pharmacists can be instrumental in assisting patients with using OTC medications safely and effectively.
ª Pharmacists should warn consumers of the risks of misusing OTC pain relievers.
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