Drug Interactions of Metformin:

       

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788205/

https://www.researchgate.net/publication/322913924_Drug_Interactions_of_Metformin_Involving_Drug_Transporter_Proteins

More Presentations from Naina Mohamed, PhD

   §    Metformin is usually a first-line drug to treat Type 2 diabetes mellitus.

   §    Metformin is also found to be useful to treat various conditions include…

ª    Prediabetes

ª    Gestational diabetes mellitus (GDM)

ª    Polycystic Ovarian Syndrome (PCOS)

ª    Obesity

ª    Cancer, etc.

   §    Interaction between one or more coadministered medications leading to reduced therapeutic efficacy or enhanced toxicity is termed as “Adverse drug interaction”.

   §   Mechanism of action of Metformin: 

   §    Most of the drug interactions of Metformin result in enhanced risk of “Metformin Associated Lactic Acidosis (MALA)”.

   §    The symptoms of MALA include…

ª    Nausea

ª    Vomiting

ª    Fatigue

ª    Lethargy

ª    Confusion

ª    Abdominal pain

ª    Thirst

   §    Concurrent use of the following drugs along with Metformin, elevate its plasma concentrations and the risk of MALA…

ª    Iodinated Contrast Materials (ICMs)

ª    H₂ receptor blockers (Cimetidine, Ranitidine)

ª    Proton pump inhibitors

ª    Antimicrobials (Trimethoprim, Cephalexin, Rifampin, Dolutegravir)

ª    Ranolazine

ª    Anticancer Drugs (Vandetanib, Imatinib, Nilotinib, Gefitinib, and Erlotinib)

ª    Beta adrenergic blockers (Atenolol, Metoprolol)

   §    The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

   §    The diabetic patients should always consult their physician and pharmacist before taking any new medication.

   §    The diabetic patients should bring a list of all of the drugs they are taking (or simply bring the drugs themselves), including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

   §    They are encouraged to ask their doctor or pharmacist to look over their list for any potentially dangerous combinations.

   §    It is recommended that people fill all their prescriptions at one pharmacy, if possible.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788205/