https://www.researchgate.net/publication/326145863_Pharmacologically_relevant_drug_interactions_of_sulfonylurea_antidiabetics_with_common_herbs
http://www.herbmedpharmacol.com/Abstract/jhp-1280
http://www.herbmedpharmacol.com/Abstract/jhp-1280
§ Sulfonylurea (SUs) antidiabetics include first-generation drugs
such as Tolbutamide, Chlorpropamide, etc and second-generation drugs like
gliclazide, glipizide, glibenclamide, etc.
§ They are insulin
secretogogues, which induce the release of insulin from beta cells of pancreas
and decrease the blood sugar levels.
§ Herbs decreasing the therapeutic efficacy of SUs
Ø St John’s Wort (Hypericum perforatum)
Ø Ginkgo biloba
§ Fruit Juices increasing the exposure of SUs
Ø Pomegranate (Punica granatum) juice
Ø Pineapple juice
§ Herbs potentiating hypoglycemic activity of SUs
Ø Bitter melon or bitter gourd (Momordica charantia)
Ø Fenugreek (Trigonella foenum-graceum)
Ø Cinnamon
Ø Gymnema (Gymnema sylvestre)
Ø Ginseng
Ø Ginger (Zingiber officinale)
Ø Garlic (Allium sativum)
Ø Aloe vera (Aloe barbadensis Miller)
Ø Sesame (Sesamum indicum) oil
Ø Andrographis paniculata
Ø Neem (Azadirachta indica)
§ Healthcare professionals through the screening, education, and
follow up on suspected drug interactions could reduce the risk of adverse
effects.
§ The diabetic patients should always consult their physician and
pharmacist before taking any new medication.
§ The diabetic patients should bring a list of all of the drugs they
are taking (or simply bring the drugs themselves), including prescription
drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during
their visit to the doctor or pharmacist.
§ They are encouraged to ask their doctor or pharmacist to look over
their list for any potentially dangerous combinations.
§ It is recommended that people fill all their prescriptions at one
pharmacy, if possible.
