Drug Interactions of Sulfonylurea Antidiabetics with Common Herbs:

https://www.researchgate.net/publication/326145863_Pharmacologically_relevant_drug_interactions_of_sulfonylurea_antidiabetics_with_common_herbs


http://www.herbmedpharmacol.com/Abstract/jhp-1280

  §    Sulfonylurea (SUs) antidiabetics include first-generation drugs such as Tolbutamide, Chlorpropamide, etc and second-generation drugs like gliclazide, glipizide, glibenclamide, etc.

  §     They are insulin secretogogues, which induce the release of insulin from beta cells of pancreas and decrease the blood sugar levels.

  §    Herbs decreasing the therapeutic efficacy of SUs

Ø St John’s Wort (Hypericum perforatum)

Ø Ginkgo biloba

  §    Fruit Juices increasing the exposure of SUs

Ø Pomegranate (Punica granatum) juice

Ø Pineapple juice

  §    Herbs potentiating hypoglycemic activity of SUs

Ø Bitter melon or bitter gourd (Momordica charantia)

Ø Fenugreek (Trigonella foenum-graceum)

Ø Cinnamon

Ø Gymnema (Gymnema sylvestre)

Ø Ginseng

Ø Ginger (Zingiber officinale)

Ø Garlic (Allium sativum)

Ø Aloe vera (Aloe barbadensis Miller)

Ø Sesame (Sesamum indicum) oil

Ø Andrographis paniculata

Ø Neem (Azadirachta indica)

  §    Healthcare professionals through the screening, education, and follow up on suspected drug interactions could reduce the risk of adverse effects.

  §    The diabetic patients should always consult their physician and pharmacist before taking any new medication.

  §    The diabetic patients should bring a list of all of the drugs they are taking (or simply bring the drugs themselves), including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

  §    They are encouraged to ask their doctor or pharmacist to look over their list for any potentially dangerous combinations.

  §    It is recommended that people fill all their prescriptions at one pharmacy, if possible.

http://www.herbmedpharmacol.com/Abstract/jhp-1280