· Nitro
vasodilators include
Ø Short-acting
nitrates
o
Nitroglycerin (GTN)
Ø Long-acting
nitrates
o
Isosorbide Mononitrate (ISMN)
o
Isosorbide Dinitrate (ISDN)
Ø Others
o
Sodium nitroprusside
o
Nicorandil
· Nitro
vasodilators are useful in the management of
Ø Coronary
artery disease
Ø Chronic
congestive failure
Ø Arterial
hypertension
· The
risk of severe hypotension may occur due to the interaction between Nitro
vasodilators and drugs like
Ø PDE5
inhibitors (Sildenafil, Tadalafil, etc.)
Ø Riociguat
· The
prescribers and the pharmacists are required to be aware of the drugs increasing
the risk of hypotension to predict and prevent the drug interactions of Nitro
vasodilators.
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