Sunday, 13 April 2014

P –Glycoprotein (P-gp) – Drug Interactions:



v P-glycoprotein is one of the transporter protein and it helps the drugs and endogenous substances to cross biological membranes, by carrier-mediated processes.
v P-gp Substrates:
Digoxin, Loperamide, Quinidine, Vinblastine, Talinolol.
v P-gp Inducers:
Carbamazepine, Phenytoin, Rifampin, St John’s wort.
v P-gp Inhibitors:
Amiodarone, Azithromycin, Captopril, Cyclosporine, Quinidine, Quinine, Reserpine, Ritonavir, Tacrolimus, Valspodar, Verapamil.
v P-glycoprotein is an efflux pump found in the membranes of certain cells, which can push metabolites and drugs out of the cells and affect drugs’
ü Absorption (in the intestine)
ü Distribution (to the brain, testis, or placenta)
ü Elimination (in the urine and bile) of drugs
v Many drugs which are substrates for CYP3A4 are also substrates for P-glycoprotein.
v There is an overlap between CYP3A4 and P-glycoprotein inhibitors, inducers and substrates.

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Drug Interactions of Thiazide Diuretics:

https://www.researchgate.net/publication/342864519_Pharmacodynamic_interactions_of_thiazide_diuretics http://www.ijmdc.com/?mno=51031...