Drug Interactions of Organic Nitrates:
© Organic nitrates include Isosorbide dinitrate, Isosorbide mononitrate, Nitroglycerin (GTN), Erythrityl tetranitrate and Pentaerythritol tetranitrate.
© Organic nitrates are commonly used to treat angina pectoris, myocardial infarction, and congestive heart failure.
© Nitroglycerine may be useful to lower blood pressure in acute hypertensive emergencies resulting from a pheochromocytoma, renal artery stenosis, aortic dissection, etc. Nitrodilators may also be used during surgery to control arterial pressure within desired limits.
© Mechanism of Action of Organic nitrates in Angina pectoris:
© Mechanism of action of Organic nitrates in Heart Failure:
© Organic nitrates can interact with drugs such as PDE 5 Inhibitors (Sildenafil, Tadalafil, Vardenafil, Avanafil) and Riociguat.
© Concomitant use of Organic nitrates and PDE 5 Inhibitors such as Sildenafil, Tadalafil, Vardenafil and Avanafil is Contraindicated.
© Coadministration of Riociguat with Organic nitrates is contraindicated due to an increased risk of hypotension.
© If possible, concomitant use of Nitroglycerin (GTN) and Alteplase should be avoided.
© Careful monitoring of PTT and Heparin dose adjustment is recommended, when heparin and Nitroglycerin (GTN) are coadministered.
© The patients with hypertension should bring a list of all of the drugs they are taking including prescription drugs, over the counter (OTC) drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.
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