Drug Interactions of Arterial Vasodilators:
© Arterial Vasodilators include Hydralazine and Minoxidil.
© Arterial Vasodilators are
commonly used to treat Systemic and Pulmonary hypertension, heart failure and angina.
© Hydralazine can interact moderately with drugs such as Beta blockers (Propranolol, Oxprenolol, Metoprolol), Indomethacin, Ma Huang (Ephedra) and Yohimbine.
© The risk of adverse effects (Bradycardia, Fatigue, and Bronchospasm) of Beta blockers is elevated by the concurrent use of Hydralazine and Beta blockers. Switch to a sustained release beta blocker, if concurrent therapy of Hydralazine and Beta blockers is required.
© Concomitant use of Hydralazine and Indomethacin warrants monitoring of blood pressure.
© Due to ephedrine content of Ma Huang, concomitant use of Ma huang is not advised in patients using antihypertensives.
© Use of Ma huang is contraindicated in patients who are ephedrine or pseudoephedrine sensitive, and those with renal failure or pheochromocytoma.
© Avoid concomitant use of Hydralazine or Minoxidil and yohimbine.
© Maintenance of consistent dosing of Hydralazine is recommended with relation to meals.
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