ª Grape fruit juice (GFJ) can interact with more than 85 medications including Simvastain, Lovastatin, Amiodarone, Dronedarone, Erythromycin, Domperidone, Nilotinib, Sunitinib, Cyclosporine, Tacrolimus, Sirolimus, Everolimus, Ketamine, Alfentanil, Fentanyl, Oxycodone, Methadone, Terfenadine, Diazepam, Midazolam, Triazolam, Felodipine, Manidipine, Nisoldipine, Ethinylestradiol, Fluvoxamine, Sertraline, Fluoxetine,Trazodone, etc.
ª GFJ contains Furanocoumarins which could inhibit the body's CYP3A4 metabolizing enzyme resulting in to toxic drug levels.
ª GFJ consumption could elevate the risk of Rhabdomyolysis in patients taking lipid regulating drugs like Simvastatin or Lovastatin.
ª The drugs like Dronedarone, Amiodarone, Erythromycin, Domperidone, Nilotinib or Sunitinib can interact with GFJ resulting in to increased risk of Torsades de pointes.
ª The risk of Nephrotoxicity might be raised by the consumption of GFJ along with drugs like Cyclosporine, Tacrolimus, Sirolimus or Everolimus.
ª The patients consuming GFJ along with the drugs such as Ketamine, Alfentanil, Fentanyl or Oxycodone could be at the increased risk of Respiratory Depression.
ª Patients should ask a pharmacist or other health care provider if they can drink grapefruit and other juices with prescribed medications.
ª The adverse drug interactions of GFJ could be minimized by Pharmacists and other health professionals who properly screen and educate patients about potential fruit juice interactions.
ª Any problems can be solved by avoiding grapefruit juice (GFJ).
