Drug Interactions of Anticoagulants (Part 7)

Drug Interactions of Dabigatran:

More Presentations from Naina Mohamed, PhD

©   Dabigatran is a direct Thrombin Inhibitor.

©   Dabigatran is used to prevent strokes in patients with Atrial Fibrillation and to treat and prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) in some circumstances.

©   Mechanism of action of Dabigatran:

©   Concomitant use of Dabigatran and Itraconazole or Ketoconazole is contraindicated due to heightened risk of bleeding.

©   The risk of Thrombosis might be elevated by the coadministration of Dabigatran with P-Glycoprotein Inducers (Carbamazepine, Rifampin, St. John's wort)

©    Drugs increasing the risk of Dabigatran associated bleeding, include…

·      P- Glycoprotein inhibitors (Verapamil,  Quinidine, Amiodarone, Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Nelfinavir, Tacrolimus, Cyclosporine)

·      Heparin

·      Enoxaparin

·      Dalteparin

·      Tinzaparin

·      Fondaparinux

·      Phenindione

·      Bivalirudin

·      Lepirudin

·      Danaparoid

·      Rivaroxaban

·      Apixaban

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients with clotting disorders should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients on Anticoagulants about their herbal and other alternative medicine product use.

Drug Interactions of Anticoagulants (Part 6)

Drug Interactions of Argatroban:

More Presentations from Naina Mohamed, PhD

©   Argatroban is a direct, synthetic Thrombin Inhibitor.

©   Argatroban is useful in the prophylaxis or treatment of thrombosis in adult patients with Heparin-induced Thrombocytopenia (HIT).

©   Argatroban is also indicated during Percutaneous Coronary Intervention (PCI) in adult patients at risk for HIT.

©   Drugs increasing the risk of Argatroban associated bleeding, include…

·      Heparin

·      Enoxaparin

·      Dalteparin

·      Tinzaparin

·      Fondaparinux

·      Phenindione

·      Bivalirudin

·      Lepirudin

·      Danaparoid

·      Rivaroxaban

·      Apixaban

·      Dabigatran

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients with clotting disorders should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients on Anticoagulants about their herbal and other alternative medicine product use.