· Common
non-dihydropyridine (non-DHP) Calcium channel blockers (CCBs) include
Ø Verapamil
Ø Diltiazem
· Non-DHP
CCBs are useful in the management of
Ø Angina
Ø Certain
arrhythmias
Ø Hypertension
· Non-dihydropyridine
CCBs are known inhibitors of CYP3A enzymes and P-gp transporter and hence they
can potentiate the adverse effects of object drugs through the inhibition of
their metabolism.
Verapamil
Interactions
· As
a precipitant drug Verapamil increase the plasma concentrations of
Ø Digoxin
Ø Cyclosporine
Ø Dofetilide
Ø Lomitapide
Ø Colchicine
Ø Carbamazepine
Ø Quinidine
Ø Dronedarone
Ø Flibanserin
Ø Statins
(simvastatin, lovastatin)
Ø Palbociclib
Ø Buspirone
Ø Macrolide
antibiotics (erythromycin, telithromycin)
· As
an object drug Verapamil interacts with
Ø Rifampicin
Diltiazem
Interactions
· As
a precipitant drug Diltiazem increase the plasma concentrations of
Ø Cyclosporine
Ø Colchicine
Ø Carbamazepine
Ø Cisapride
Ø Quinidine
Ø Benzodiazepines
(diazepam, midazolam, triazolam)
Ø Fentanyl
Ø Dronedarone
Ø Flibanserin
Ø Beta-blockers
(propranolol, metoprolol)
Ø Apixaban
Ø Statins
(simvastatin, lovastatin)
Ø Buspirone
· As
an object drug Diltiazem interacts with
Ø Clarithromycin
Ø Amiodarone
· The
prescribers and the pharmacists are required to be aware of the drugs being as
substrates of CYP3A4 enzyme and P-gp transporter to predict and prevent the
drug interactions of nondihydropyridine CCBs.
