Drug Interactions of Vorapaxar:
© Vorapaxar is an antiplatelet drug and it is the antagonist of Protease
activated receptor-1 (PAR-1) (Thrombin Receptor).
©
Vorapaxar
is useful in the secondary prevention of atherothrombotic events
occurring in patients with a history of myocardial infarction or
peripheral arterial disease.
© Mechanism of action of Vorapaxar:
© Vorapaxar is a substrate of CYP3A4 enzyme and its exposure is expected to be
elevated by CYP3A4 inhibitors such as…
Ø Ketoconazole
Ø Itraconazole
Ø Posaconazole
Ø Clarithromycin
Ø Nefazodone
Ø Ritonavir
© CYP3A4 inducers
decrease Vorapaxar exposure which include…
Ø Rifampin
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The patients on antiplatelet therapy should bring a list of all of
the drugs they are taking including prescription drugs, over-the-counter drugs,
and any supplements, herbal or otherwise, during their visit to the doctor or
pharmacist.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© If possible, the patients are recommended to fill all their prescriptions
at one pharmacy.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients about their herbal and other alternative
medicine product use.
