Drug Interactions of Exenatide and Pramlintide:
¢ More frequent monitoring of INR is recommended when initiating or changing the dose of exenatide during Warfarin therapy due to increased risk of bleeding.
¢ To avoid Digoxin toxicity, the plasma levels and clinical efficacy of digoxin should be monitored when Exenatide is used concurrently.
¢ Antibacterials should be taken at least one hour before Exenatide, to prevent delayed absorption and reduced efficacy of antibacterials.
¢ Increased dose of Exenatide or Pramlintide may be required due to its interaction with Thyroid hormones which decrease its effectiveness.
¢ Danazol is associated with insulin resistance and it interacts with Exenatide or Pramlintide to increase blood sugar level.
¢ The risk of hypoglycemia is increased by the concomitant use of Exenatide or Pramlintide and Trandolapril.
¢ The diabetics should bring a list of all of the drugs they are taking, including prescription drugs, over-the-counter drugs, and any supplements, herbal products, etc. during their visit to the doctor or pharmacist, to minimize the possibility of potentially dangerous combinations.
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