Saturday, 16 July 2016

Drug Interactions of Lipid Lowering Drugs (Part 3):


Drug Interactions of Bile Acid Sequestrants:


Drug Interactions of Bile acid sequestrants



More presentations from Naina Mohamed Pakkir Maideen


©   Bile Acid Sequestrants or Ion-exchange resins include Cholestyramine, Colestipol, and Colesevelam.

©   Bile Acid Sequestrants are used occasionally to treat Hyperlipidemia, as an adjunct to the statins. Bile acid sequestrants are also used as the principal therapy for bile acid-induced diarrhea.


©   Bile Acid Sequestrants interact majorly with drugs such as Deferasirox, Bezafibrate, Mycophenolate, etc.

©   Monitor serum ferritin levels and clinical response, when Bile acid sequestrants and Deferasirox are coadministered.

©   Separate the administration of Bezafibrate and Bile acid sequestrants by at least 2 hours.

©   It is recommended to avoid the coadministration of Bile acid sequestrants and Mycophenolate.

©   The patients are advised to take Pravastatin 1 hour before or 4 hours after Colesevelam.

©   The interaction between Colesevelam and Levothyroxine can be avoided by separating the administration of the two drugs by at least 4 hours.

©   The occurrence of significant morbidity and mortality can be reduced by minimizing the risk for drug interactions.

©   The hyperlipidemic patients should bring a list of all the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the Doctor or Pharmacist.

©   The risk of adverse effects could be reduced and the quality of life for patients improved by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the hyperlipidemic patients are recommended to fill all their prescriptions at one pharmacy.


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Drug Interactions of Thiazide Diuretics:

https://www.researchgate.net/publication/342864519_Pharmacodynamic_interactions_of_thiazide_diuretics http://www.ijmdc.com/?mno=51031...