Drug Interactions of Ezetimibe:
© Ezetimibe is used
as second line therapy to treat high LDL cholesterol levels in patients who are
intolerant to statins or who are unable to achieve target with statins alone.
© Mechanism of Action of Ezetimibe:
© Ezetimibe can interact majorly with Fibrates
(Gemfibrozil, Clofibrate, etc) and moderately with Bile acid
sequestrants (Cholestyramine, Colestipol, Colesevelam), Warfarin and
Cyclosporine.
© Coadministration of Ezetimibe and a Fibrate
except fenofibrate, is not recommended.
© To minimize reductions in ezetimibe
bioavailability, Ezetimibe should be administered at least two hours before or
four hours after Bile acid sequestrants such as Cholestyramine, Colestipol and
Colesevelam.
© Frequent monitoring of Prothrombine Time or INR
is recommended, if ezetimibe and warfarin are used concomitantly. Warfarin
dosage should be adjusted accordingly.
© Monitor for signs and symptoms of ezetimibe
toxicity including abdominal, back or headache pain, fatigue, diarrhea,
sinusitis, and cough when Ezetimibe and Cyclosporine are used concomitantly.
© The occurrence of significant morbidity and
mortality can be reduced by minimizing the risk for drug interactions.
© The hyperlipidemic patients should bring a list
of all the drugs they are taking including prescription drugs, over-the-counter
drugs, and any supplements, herbal or otherwise, during their visit to the Doctor
or Pharmacist.
© The risk of adverse effects could be reduced
and the quality of life for patients improved by healthcare professionals
through the screening, education, and follow up on suspected drug interactions.
© If possible, the hyperlipidemic patients are
recommended to fill all their prescriptions at one pharmacy.
No comments:
Post a Comment