Abnormally
elevated levels of lipids (Cholesterol (Hypercholesterolemia) or
Triglycerides (Hypertryglyceridemia)) is termed as Hyperlipidemia.
© Types of Hyperlipidemia:
ü Primary (Familial) Hyperlipidemia
Ø Hypolipoproteinemia type I
Ø Hyperlipoproteinemia type II
Ø Hypolipoproteinemia Type IIa
Ø Hypolipoproteinemia Type IIb
Ø Hyperlipoproteinemia type III
Ø Hyperlipoproteinemia type IV
Ø Hyperlipoproteinemia type V
ü Secondary (Acquired) Hyperlipidemia – Associated with Fatty
foods, Physical inactivity, Obesity and Diabetes.
©
Classification of Antihyperlipidemics:
Ø Statins (HMG CoA
Reductase Inhibitors) - Simvastain,
Lovastatin, Atorvastatin, Rosuvastatin, Pravastatin, etc.
Ø Fibrates - Gemfibrozil, Clofibrate, Fenofibrate,
etc.
Ø Bile acid
Sequestrants - Cholestyramine,
Colestipol and Colesevelam
Ø Niacin
Ø Ezetimibe
Ø Lomitapide
© Contraindicated Combinations include…
Ø Simvastatin or
Lovastatin + CYP3A4 Inhibitors (Azole Antifungals (Fluconazole, etc), Macrolide Antibiotics (Clarithromycin,
etc), Protease Inhibitors – Antivirals (Ritonavir, etc) etc)
Ø Simvastatin +
Gemfibrozil
Ø Gemfibrozil +
Repaglinide
Ø Gemfibrozil +
Dasabuvir
Ø Fibrates +
Ciprofibrate
Ø Lomitapide +
CYP3A4 Inhibitors (Azole antifungals – Ketoconazole, Macrolide
antibiotics – Clarithromycin, etc)
© Combinations
elevating the risk of
Rhabdomyolysis include…
Rhabdomyolysis include…
Ø Simvastatin or
Lovastatin + CYP3A4 Inhibitors (Azole Antifungals (Fluconazole, etc), Macrolide Antibiotics (Clarithromycin,
etc), Protease Inhibitors – Antivirals (Ritonavir, etc) etc)
Ø Simvastatin +
Gemfibrozil
Ø Fibrates + Ciprofibrate
Ø Statins + Warfarin
Ø Statins + Colchicine
Ø Statins + Daptomycin
Ø Statins + Grapefruit Juice
Ø Statins + Niacin
Ø Simvastatin + Ciprofloxacin
Ø Simvastatin + Amlodipine
Ø Simvastatin + Tadalafil
Ø Simvastatin+ Cranberry
Juice
© The occurrence
of significant morbidity and mortality can be reduced by minimizing the risk
for drug interactions.
© The
hyperlipidemic patients should bring a list of all the drugs they are taking
including prescription drugs, over-the-counter drugs, and any supplements,
herbal or otherwise, during their visit to the Doctor or Pharmacist.
© The risk of
adverse effects could be reduced and the quality of life for patients improved
by healthcare professionals through the screening, education, and follow up on
suspected drug interactions.
© The
hyperlipidemic patients are recommended to fill all their prescriptions at one
pharmacy, if possible.
No comments:
Post a Comment