Clinically Important Drug Interactions in Hypothyroidism:

More presentations from Naina Mohamed Pakkir Maideen

       > Hypothyroidism is a condition in which the Thyroid gland is underactive and produces insufficient Thyroid hormone. 

Ø Symptoms of Hypothyroidism include…

·      Fatigue

·      Weakness

·      Weight gain

·      Dry, rough pale skin

·      Dry hair

·      Hair loss

·      Cold intolerance

·      Muscle cramps and frequent muscle aches

·      Constipation

·      Depression

·      Irritability

·      Memory loss

·      Abnormal menstrual cycles

·      Decreased libido

Ø Levothyroxine may interact significantly with drugs such as…

·      Estrogens

·      Calcium supplements

·      Iron supplements

·      Proton Pump Inhibitors

·      Simvastatin

·      Tricyclic or Tetracyclic Antidepressants

·      Ketamine

·      Bile acid sequestrants (Cholestyramine, Colestipol, Colesevelam)

·      Ciprofloxacin

·      Oral Anticoagulants

·      Antacids, Orlistat Or Sucralfate

·      CYP3A4 Inducers (Phenobarbital,  Carbamazepine, Phenytoin, Rifampin)

Ø Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

Ø The patients with Hypothyroidism should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

Ø The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

Ø If possible, the patients are recommended to fill all their prescriptions at one pharmacy.