Top 10 Dangerous Drug Interactions

·       According to American Medical Directors Association (AMDA) and American Society of Consultant Pharmacists (ASCP) the following are summerised as top 10 dangerous drug combinations…

      1. Warfarin and NSAIDs

      2. Warfarin and Sulpha drugs

      3. Warfarin and Macrolides

      4. Warfarin and Quinolones

      5. Warfarin and Phenytoin

      6. ACE inhibitors and Potassium supplements

      7. ACE inhibitors and Spiranolactone

      8. Digoxin and Amiodarone

      9. Dogoxin and Verapamil

    10. Theophylline and Quinolones

·       Warfarin increases the GI bleeding risk when it is coadministered with NSAIDs.

·       Concomitant administration of Warfarin and sulpha drugs may elevate the risk of bleeding.

·       The risk of bleeding is increased by the interaction of warfarin with macrolide antibiotics such as Erythromycin, clarithromycin and telithromycin.

·       Bleeding risk is raised by the coadministration of warfarin and Quinolones too.

·       The risk of bleeding is varied with individuals due to the action of phenytoin on the metabolism of warfarin and its diaplacement from protein binding.

·       Coadministration of ACE inhibitors and Potassium supplements may increase the risk of hyperkalemia.

·       Hyperkalemia risk is also increased by the concomitant administration of ACE inhibitors and Spiranolactone.

·       Digoxin toxicity is induced when digoxin and amiodarone are administered together.

·       Digoxin toxicity is also induced by the concomitant administration of digoxin and verapamil.

·       Concomitant administration of Theophylline and Quinolones, increases the risk of Theophylline toxicity.