© Ibuprofen is an OTC analgesic and is used to treat pain or inflammation and to reduce fever.
© Ibuprofen can cause serious adverse effects by interacting with other common medications such as anticoagulants, corticosteroids, or antihypertensive agents.
© Use of Ibuprofen by Ketorolac patients, is contraindicated due to cumulative risks of inducing serious NSAID-related adverse events such as peptic ulcers, gastrointestinal bleeding and/or perforation.
© The risk of bleeding is increased by Ibuprofen in patients taking Warfarin, Danaparoid, Heparin, Low Molecular Weight Heparins (LMWHs) (Enoxaparin, Dalteparin, Tinzaparin, etc.), Coumarins and other anticoagulants (Acenocoumarol, Dicumarol, Phenprocoumon, Dabigatran, Anisindione, Phenindione), Direct thrombin inhibitors (Dabigatran, Desirudin, Lepirudin, Bivalirudin, Argatroban), Direct factor Xa inhibitors (Apixaban, Rivaroxaban), Antiplatelets (Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Ticlopidine, Dipyridamole, Abciximab, Eptifibatide, Tirofiban), Fondaparinux, Selective serotonin reuptake inhibitors (SSRIs) (Escitalopram, Fluvoxamine, Paroxetine, Vortioxetine, Sertraline, Nefazodone, vilazodone), Selective serotonin and norepinephrine reuptake inhibitors (SNRIs) (Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran, Sibutramine), Cilostazol, Protein C, Pentoxyfilline, Ginkgo, Meadowsweet, Erlotinib and Gossypol.
© The antihypertensive effects of ACE Inhibitors (Captopril, Enalapril, Imidapril, Temocapril, Delapril, Ramipril, Perindopril, Cilazapril), Angiotensin II receptor blockers (ARBs) (Losartan, Valsartan, Telmisartan), Beta adrenergic blockers, Calcium Channel Blockers, Thiazide Diuretics, Loop Diuretics and Potassium sparing Diuretics.
© The plasma levels of ibuprofen is elevated by the co-administration of Amiodarone, Voriconazole and Mifepristone by inhibiting CYP2C9-mediated ibuprofen metabolism.
© By decreasing renal prostacyclin synthesis, Ibuprofen may increase the risk of Cyclosporine associated nephrotoxicity, Tacrolimus associated acute renal failure and Lithium toxicity (weakness, tremor, excessive thirst, confusion).
© Ibuprofen may increase the toxicity of Methotrexate, Pralatrexate and Premetrexed by decreasing their renal clearance.
© Concomitant use of Ibuprofen and Fluoroquinolones (Ofloxacin, Levofloxacin, Norfloxacin) may elevate the risk of seizures.
© Due to the risk of earlier closure of ductus arteriosus, Ibuprofen should be avoided after 30 weeks gestation in Pregnant women.
© Patients should thoroughly read the labels of all over-the-counter and prescription medicines.
© Patients should talk to their doctor or pharmacist before taking any new prescription or over the counter medication.
© Physicians should be aware of potential drug interactions with OTC medicines when prescribing new medications.
© Pharmacists can be instrumental in assisting patients with using OTC medications safely and effectively.
© Pharmacists should warn consumers of the risks of misusing OTC pain relievers.
No comments:
Post a Comment