Drug Interactions of Ketoprofen:
vKetoprofen is a Non Steroidal Anti-inflammatory drug (NSAID) and is available as an OTC analgesic drug which is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.
vConcomitant use of Ketorolac and Ketoprofen is contraindicated due to cumulative risks of inducing serious NSAID-related adverse events (peptic ulcers, gastrointestinal bleeding and/or perforation).
vBleeding risk is elevated by the coadministration of Ketoprofen with drugs such as Warfarin, Heparin, Low Molecular Weight Heparins (LMWHs) (Enoxaparin, Dalteparin, Tinzaparin, etc.), Coumarins and other anticoagulants (Acenocoumarol, Dicumarol, Phenprocoumon, Dabigatran, Anisindione, Phenindione), Direct thrombin inhibitors (Dabigatran, Desirudin, Lepirudin, Bivalirudin, Argatroban), Direct factor Xa inhibitors (Apixaban, Rivaroxaban), Antiplatelets (Clopidogrel, Aspirin, Prasugrel, Ticagrelor, Ticlopidine, Dipyridamole, Abciximab, Eptifibatide, Tirofiban), Danaparoid, Fondaparinux, Selective serotonin reuptake inhibitors (SSRIs) (Escitalopram, Fluvoxamine, Paroxetine, Vortioxetine, Sertraline, Nefazodone, vilazodone), Selective serotonin and norepinephrine reuptake inhibitors (SNRIs) (Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran, Sibutramine), Cilostazol, Protein C, Pentoxyfilline, Ginkgo, Meadowsweet, Erlotinib and Gossypol.
vUse of Ketoprofen in patients taking ACE Inhibitors (Captopril, Enalapril, Imidapril, Temocapril, Delapril, Ramipril, Perindopril, Cilazapril), Angiotensin II receptor blockers (ARBs) (Losartan, Valsartan, Telmisartan), Beta adrenergic blockers, Calcium Channel Blockers, Thiazide Diuretics and Loop Diuretics may decrease the antihypertensive effects by decreasing renal prostaglandin production.
vKetoprofen can decrease the renal prostaglandin synthesis and increase the toxicity of Cyclosporine, Tacrolimus and Lithium.
vThe toxicity of Methotrexate, Pralatrexate and Premetrexed may be elevated by the concomitant use of Ketoprofen, due to decreased clearance.
vConcomitant use of Ketoprofen and Fluoroquinolones (Ofloxacin, Levofloxacin, Norfloxacin) may elevate the risk of seizures.
vDue to the risk of earlier closure of ductus arteriosus, Ketoprofen should be avoided after 30 weeks of gestation in Pregnant women.
vPatients should thoroughly read the labels of all over-the-counter and prescription medicines.
vPatients should talk to their doctor or pharmacist before taking any new prescription or over the counter medication.
vPhysicians should be aware of potential drug interactions with OTC medicines when prescribing new medications.
vPharmacists can be instrumental in assisting patients with using OTC medications safely and effectively.
vPharmacists should warn consumers of the risks of misusing OTC pain relievers.
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