Drug Interactions of Anticoagulants (Part 7)

Drug Interactions of Dabigatran:

More Presentations from Naina Mohamed, PhD

©   Dabigatran is a direct Thrombin Inhibitor.

©   Dabigatran is used to prevent strokes in patients with Atrial Fibrillation and to treat and prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) in some circumstances.

©   Mechanism of action of Dabigatran:

©   Concomitant use of Dabigatran and Itraconazole or Ketoconazole is contraindicated due to heightened risk of bleeding.

©   The risk of Thrombosis might be elevated by the coadministration of Dabigatran with P-Glycoprotein Inducers (Carbamazepine, Rifampin, St. John's wort)

©    Drugs increasing the risk of Dabigatran associated bleeding, include…

·      P- Glycoprotein inhibitors (Verapamil,  Quinidine, Amiodarone, Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Nelfinavir, Tacrolimus, Cyclosporine)

·      Heparin

·      Enoxaparin

·      Dalteparin

·      Tinzaparin

·      Fondaparinux

·      Phenindione

·      Bivalirudin

·      Lepirudin

·      Danaparoid

·      Rivaroxaban

·      Apixaban

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients with clotting disorders should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients on Anticoagulants about their herbal and other alternative medicine product use.