Drug Interactions of Anticoagulants (Part 6)

Drug Interactions of Argatroban:

More Presentations from Naina Mohamed, PhD

©   Argatroban is a direct, synthetic Thrombin Inhibitor.

©   Argatroban is useful in the prophylaxis or treatment of thrombosis in adult patients with Heparin-induced Thrombocytopenia (HIT).

©   Argatroban is also indicated during Percutaneous Coronary Intervention (PCI) in adult patients at risk for HIT.

©   Drugs increasing the risk of Argatroban associated bleeding, include…

·      Heparin

·      Enoxaparin

·      Dalteparin

·      Tinzaparin

·      Fondaparinux

·      Phenindione

·      Bivalirudin

·      Lepirudin

·      Danaparoid

·      Rivaroxaban

·      Apixaban

·      Dabigatran

©   Drug interactions can result in significant morbidity and mortality and thus minimizing the risk for drug interactions should be a goal in drug therapy.

©   The patients with clotting disorders should bring a list of all of the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist.

©   The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.

©   If possible, the patients are recommended to fill all their prescriptions at one pharmacy.

©   Pharmacists can play a crucial role in identifying possible drug interactions by asking patients on Anticoagulants about their herbal and other alternative medicine product use.