Drug Interactions of Streptokinase:
More presntations from Naina Mohamed, PhD
© Streptokinase is a Fibrinolytic agent and it is isolated and purified from
streptococci bacteria.
© Our body develops an immunity to Streptokinase, since it is
a bacterial product. Hence, it is
not recommended to use Streptokinase again after four days from the first
administration. Further thrombotic events could be treated with Recombinant Tissue Plasminogen Activators (rtPA) such as Alteplase, Reteplase and Tenecteplase.
© Streptokinase is used in Acute Myocardial Infarction, Arterial and
Venous Thrombosis and Pulmonary Embolism.
© Due to the lack of fibrin specificity of Streptokinase, it produces
more fibrinogenolysis which makes it a less desirable thrombolytic drug than rtPA compounds.
© Overdose of Streptokinase or rtPA can be treated
with Aminocaproic acid.
© Concurrent use of Streptokinase and Antiplatelet agents such as Aspirin, Dipyridamole and
Clopidogrel results in elevated risk
of Bleeding.
© It is Contraindicated to use Fibrinolytics and
Defibrotide concomitantly.
© Drugs increasing the risk of
Fibrinolytics associated Bleeding include…
o
Anticoagulants (Warfarin,
Heparin, Enoxaparin, Dabigatran, etc)
o
Antiplatelet agents
(Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate
Sodium
©
Herbs
increasing the risk of Fibrinolytics associated Bleeding include…
o
Fenugreek
o
Garlic
o
Ginkgo
o
Evening Primrose Oil
o
Clove Oil
o
Anise
o
Turmeric (Curcumin)
o
Licorice
o
Asafetida
o
Capsicum (Capsaicin)
o
Celery
o
Kava
o
Cat's claw
o
Medowsweet
o
Feverfew
o
Tan-shen
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients on Anticoagulants about their herbal and other
alternative medicine product use.
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