Drug Interactions of Urokinase:
© Urokinase is a Fibrinolytic agent and it was originally isolated from
human urine.
© Urokinase is also present in
the blood and in the extracellular matrix of many tissues.
© Urokinase could be used to treat Deep Venous Thrombosis
(DVT), Pulmonary Embolism (PE) and Myocardial Infarction (MI).
© It is Contraindicated to use Fibrinolytics and
Defibrotide concomitantly.
© Drugs increasing the risk of
Fibrinolytics associated Bleeding include…
o
Anticoagulants (Warfarin,
Heparin, Enoxaparin, Dabigatran, etc)
o
Antiplatelet agents
(Aspirin, Clopidogrel, etc)
o Pentosan
Polysulfate Sodium
©
Herbs
increasing the risk of Fibrinolytics associated Bleeding include…
o
Fenugreek
o
Garlic
o
Ginkgo
o
Evening Primrose Oil
o
Clove Oil
o
Anise
o
Turmeric (Curcumin)
o
Licorice
o
Asafetida
o
Capsicum (Capsaicin)
o
Celery
o
Kava
o
Cat's claw
o
Medowsweet
o
Feverfew
o
Tan-shen
© Drug interactions can result in significant morbidity and mortality
and thus minimizing the risk for drug interactions should be a goal in drug
therapy.
© The risk of adverse effects could be reduced by healthcare
professionals through the screening, education, and follow up on suspected drug
interactions.
© Pharmacists can play a crucial role in identifying possible drug
interactions by asking patients on Anticoagulants about their herbal and other
alternative medicine product use.
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